Mary Pierce defeated Arantxa Sánchez Vicario in the final, 6–1, 6–0 to win the singles tennis title at the 2000 Family Circle Cup. She lost just 12 games during the tournament, surpassing Chris Evert's record of 15 games conceded during her title win in 1985.[1][2] It was the 1st title of the year for Pierce and the 14th of her career.
Martina Hingis was the reigning champion, but did not compete this year.